Stroke Trials

In patients with acute basilar artery occlusion, is first-line contact aspiration superior to first-line stent retriever thrombectomy in achieving first-pass effect (eTICI 2C/3)?

Does endovascular treatment plus best medical treatment improve 12-month functional outcomes and survival compared with best medical treatment alone in patients with medium or distal vessel occlusion stroke?

Does endovascular thrombectomy improve functional outcomes and reduce mortality versus medical management in patients with large-core ischaemic stroke presenting up to 24 h after onset?

Does adjunctive intra-arterial bolus plus 24-hour IV infusion of tirofiban after successful endovascular reperfusion improve 90-day functional independence in patients with acute ischaemic stroke from anterior-circulation large-vessel occlusion?

Does direct transfer to the angiography suite, bypassing baseline imaging, improve outcomes in patients with suspected large vessel occlusion stroke?

Does a motivational interviewing-based intervention (MIBI) plus usual care reduce post-stroke depressive symptoms at 3 months better than an attention control plus usual care and/or usual care alone?

In adults undergoing mechanical thrombectomy for anterior large-vessel-occlusion ischemic stroke, does an individualized blood pressure strategy (MAP within ±10% of the reference MAP measured pre-procedure) improve 90-day functional outcome compared with a standard SBP 140-180 mm Hg target?

In adults with acute ischemic stroke presenting >4.5 hours from last known well, does IV thrombolysis added to best medical therapy improve 90-day functional outcomes and safety compared with best medical therapy alone?

Do the short-term upper-extremity motor gains produced by paired vagus nerve stimulation plus task-based rehabilitation in chronic ischemic stroke persist through 2 years (and 3 years in a subset)?

Six weeks of intensive speech-language therapy produced significant, clinically meaningful improvements in swallowing across DOSS, PAS, MASA and SWAL-QoL in both arms, with no overall superiority of b...

In patients with large-core anterior circulation ischemic stroke selected by NCCT (ASPECTS 2-5), does intra-arterial thrombectomy plus medical management improve 1-year functional outcomes and quality of life vs medical management alone?

Can a single infusion of an in vivo adenine base-editing therapy targeting PCSK9 safely and durably lower LDL cholesterol in patients with heterozygous familial hypercholesterolemia or premature coronary artery disease?

Among patients with acute ischemic stroke due to large vessel occlusion who had successful recanalization after endovascular thrombectomy, does adjunctive intra-arterial alteplase improve functional outcomes compared with thrombectomy alone?

In 44 chronic post-stroke aphasia patients, 2 weeks of intensive Intensive Language Action Therapy (ILAT, 25 h) produced significantly greater gains on the primary language measure (mean AAT) and on d...

Does endovascular thrombectomy improve outcomes in patients with anterior circulation large vessel occlusion stroke randomly assigned 6–24 hours from time last known well?

Does access to the Stroke Riskometer mHealth application improve Life's Simple 7 cardiovascular risk factor scores at 6 months compared with usual care in adults with multiple stroke risk factors?

Does intensive systolic blood pressure lowering to <120 mmHg reduce stroke risk compared to standard treatment targeting <140 mmHg in hypertensive patients with high cardiovascular risk?

Does intensive systolic blood pressure control (<120 mm Hg) reduce cardiovascular events in patients with type 2 diabetes compared to standard control (<140 mm Hg)?

In this phase IIb trial of 120 patients with LVO stroke in the 6–24-hour window, 4 hours of 100% oxygen added to EVT significantly increased early neurological improvement (35% vs 19%; adjusted OR 2...

Ultra-early RIPC after successful EVT was safe but did not significantly improve 90-day functional independence in patients with large vessel occlusion ischemic stroke (60.9% vs 57.8%; adjusted RR 1.0...

Rapid local ischemic postconditioning initiated within 5 minutes of successful thrombectomy is feasible; four cycles of 2-minute inflation/2-minute deflation met prespecified safety (toxicity <15%) an...

In older adults without prior CVD, individuals in the highest iPGS quintile experienced a 51% relative reduction in ischemic stroke with aspirin (HR 0.49) without increased major bleeding, while no be...

Mechanical thrombectomy benefit was concentrated in patients <70 years with low cSVD burden (OR 4.16); cSVD burden — not chronological age — mediated roughly half the detrimental effect of age on ...

Clopidogrel-aspirin plus immediate intensive statin reduced 90-day new stroke vs aspirin plus delayed intensive statin (7.6% vs 9.9%, HR 0.76), but the effect was driven by DAPT with no synergistic ef...

In this early-terminated, underpowered Scandinavian trial (n=69), starting antiplatelet therapy after ICH produced numerically more recurrent ICHs and deaths and numerically fewer major ischemic event...

A pragmatic, low-tech, nurse-navigated, phone-based mHealth bundle improved 12-month systolic BP control after stroke in Ghana (67% vs 43% achieving SBP <140 mm Hg, between-group difference 24%, p<0.0...

In patients with recent cryptogenic stroke and atrial cardiopathy, does apixaban reduce incident nonlacunar covert infarcts on MRI compared to aspirin?

Can left atrial appendage closure replace NOACs for stroke prevention in anticoagulation-eligible AF patients?

Early successful recanalization independently predicts better 90-day functional outcomes in minor ischemic stroke with proven occlusion (adjusted RR 1.21), and intravenous tenecteplase is the stronges...

Intensive BP lowering (<140 mm Hg) during the first 24 hours after successful endovascular thrombectomy produces durable harm on 1-year functional recovery — significantly lower functional independe...

In this preliminary multicenter RCT, NBP 600 mg/day for 4 weeks significantly increased the proportion of patients with cerebral blood flow amelioration at 12 weeks (adjusted RR 1.32, p=0.006) without...

Does a palm-derived tocotrienol-rich vitamin E complex (HOV12020) reduce clinical progression (stroke, disability, or cognitive decline) over 24 months in patients with CADASIL?

Does adjunctive remote ischaemic conditioning improve 90-day functional outcomes in adults with acute supratentorial intracerebral haemorrhage managed without surgery?

Among patients with prior intracerebral hemorrhage, does a single pill combining three low-dose antihypertensive agents reduce recurrent stroke compared with placebo, when added to standard care?

Does recombinant factor VIIa given within 2 hours of ICH onset improve functional outcomes compared to placebo?

Does middle meningeal artery embolisation (MMAe) reduce the composite of surgical drainage need, poor clinical outcome, or clinical deterioration compared to observation alone in mildly symptomatic chronic subdural haematoma patients?

In the MT era, in-hospital stroke continues to present with greater neurological severity, longer recognition-to-imaging times, and substantially worse in-hospital outcomes than community-onset stroke...

In patients with recent noncardioembolic ischemic stroke or high-risk TIA on antiplatelet therapy, does asundexian 50 mg once daily (an activated factor XI inhibitor) reduce the risk of recurrent stroke compared with placebo?

Is IV tenecteplase plus endovascular thrombectomy (TNK + EVT) associated with better 3-month functional outcomes compared with EVT alone in patients with anterior circulation LVO stroke treated within 4.5 hours, and does any benefit vary with expected onset-to-thrombolysis time or admission center type?

Are direct oral anticoagulants (DOACs) as safe and effective as vitamin K antagonists (VKAs) for the treatment of cerebral venous thrombosis?

Is dual antiplatelet therapy more effective than intravenous alteplase in preventing early neurological deterioration in minor strokes without large vessel occlusion compared to those with large vessel occlusion?

Does peri-procedural subcutaneous semaglutide improve 90-day functional outcomes when added to endovascular thrombectomy in patients with acute LVO stroke who have not received intravenous thrombolysis?

Does staged bilateral MRgFUS thalamotomy provide meaningful and sustained tremor reduction — including midline tremor — with an acceptable safety profile in essential tremor patients who previously underwent unilateral treatment?

Does revascularization reduce stroke risk when added to optimized medical therapy in patients with asymptomatic or low-to-intermediate risk symptomatic carotid stenosis?

Among patients with asymptomatic high-grade carotid stenosis, does adding carotid revascularization (stenting or endarterectomy) to intensive medical management provide greater benefit than intensive medical management alone in preventing stroke?

Does remote ischemic conditioning added to IV thrombolysis increase the rate of excellent functional outcome (mRS 0-1) at 90 days in acute ischemic stroke?

Does targeted training of the ipsilesional (less impaired) arm improve motor performance in chronic stroke patients with severe contralesional arm paresis?

Does a BCI intervention using the ReHand-BCI system with robotic hand orthosis feedback produce greater upper extremity motor recovery and neuroplastic changes compared to a sham-BCI intervention in stroke patients with hand paresis?

Can cervical epidural spinal cord stimulation safely and effectively improve motor function and reduce spasticity in individuals with chronic post-stroke upper-limb hemiparesis?

What are the long-term effects (through 12 months) of vagus nerve stimulation (VNS) paired with rehabilitation on impairment, activity, and participation in people with upper extremity (UE) impairment after chronic ischemic stroke?

In patients with acute ischemic stroke undergoing endovascular thrombectomy under general anesthesia, does early extubation (<6 hours) improve 90-day functional outcomes compared with delayed extubation (6-12 hours)?

Among patients with atherosclerotic cardiovascular disease, is targeting an LDL cholesterol level of less than 55 mg per deciliter superior to targeting a level of less than 70 mg per deciliter for preventing recurrent major cardiovascular events?

Does extended head-to-heart CT angiography increase detection of cardioaortic thrombus in acute stroke or TIA without delaying treatment?

Does minocycline, in addition to routine treatment, improve 90-day functional outcomes compared with placebo in patients with acute ischaemic stroke presenting within 72 hours of symptom onset?

In patients with acute LVO stroke without atrial fibrillation or intracardiac thrombus, which cardiac CT findings are independently associated with a cardioembolic stroke aetiology?

Does combining Cerebrolysin with structured speech and language therapy enhance recovery from nonfluent aphasia after acute ischemic stroke?

Does loberamisal, a dual-acting neuroprotective agent, improve functional recovery when administered within 48 hours of moderate to severe acute ischemic stroke?

Does tocilizumab (IL-6 receptor blockade) improve sensorimotor recovery and reduce brain tissue loss in preclinical rodent stroke models across different age groups, sexes, and comorbidity profiles?

To determine whether time to treatment influences the effect of intraarterial thrombolysis (IAT), intravenous thrombolysis (IVT), and conservative standard therapy (CST) on visual outcomes in nonarteritic central retinal artery occlusion (CRAO).

Does tirzepatide improve obstructive sleep apnea severity and associated complications in adults with moderate-to-severe OSA and obesity?

What are the complication rates of carotid artery stenting (CAS) when performed by fellowship-trained neurointerventionalists (NIRs)?

Does lepodisiran, an siRNA targeting hepatic production of lipoprotein(a), safely and effectively reduce serum lipoprotein(a) concentrations over time?

Does clazosentan (15 mg/hour IV), an endothelin receptor antagonist, reduce clinical deterioration due to delayed cerebral ischemia when administered for up to 14 days alongside standard care (including nimodipine) in patients with aneurysmal subarachnoid hemorrhage and thick diffuse clot?

Is galantamine safe, tolerable, and potentially efficacious in improving long-term functional and cognitive outcomes in patients with aneurysmal subarachnoid hemorrhage when administered during early and subacute stages?

Does a liberal red-cell transfusion strategy, as compared with a restrictive strategy, result in a lower risk of an unfavorable neurologic outcome at 12 months in critically ill adults with acute aneurysmal subarachnoid hemorrhage and anemia?

What are the new clinical (ischemic stroke, intracranial/major extracranial bleeding, or death) and new MR-Imaging outcomes (ischemic or hemorrhagic brain lesions) between 3 and 6 months in patients with symptomatic, MR-imaging-verified cervical artery dissection treated with aspirin versus anticoagulation with vitamin K antagonists?

To compare outcomes in patients with cervical artery dissection treated with antiplatelets versus anticoagulation regarding stroke prevention and major hemorrhage.