Does oncolytic herpes virus treatment reprogram the glioblastoma immune microenvironment to enable T cell-mediated tumor killing?
rQNestin GBM
2026Oncolytic Virus for Recurrent Glioblastoma — Spatial Omics Analysis
Does oncolytic herpes virus treatment reprogram the glioblastoma immune microenvironment to enable T cell-mediated tumor killing?
Oncolytic Virus for Recurrent Glioblastoma — Spatial Omics Analysis
Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment
Cell · 2026
Bottom Line: Intratumoral rQNestin34.5v.2 induced persistent T cell activation in GBM. Spatial omics revealed granzyme B+ CD8 T cell proximity to apoptotic tumor cells correlated with survival.