Epilepsy Trials

In pregnant women taking antiseizure medications as monotherapy during the first trimester, what is the risk of major congenital malformations for each specific ASM compared to lamotrigine?

Does MRgLITT preserve cognitive function—especially naming and verbal memory—better than traditional open resection in patients with drug-resistant mesial temporal lobe epilepsy?

Does soticlestat, a first-in-class cholesterol 24-hydroxylase (CH24H) inhibitor, reduce major motor drop seizure frequency as adjunctive therapy in patients with Lennox–Gastaut syndrome?

Do levetiracetam and brivaracetam differ meaningfully in their adverse event profiles compared to placebo and to each other?

Can perampanel monotherapy at 4-8 mg/day provide sustained long-term seizure freedom and acceptable tolerability in adolescent and adult patients with newly diagnosed or currently untreated recurrent focal-onset seizures?