Neurology, distilled.

Multicentre development and external validation of MORGOTH, a foundation model for comprehensive automated EEG interpretation across 7 event-level and 17 EEG-level clinical tasks, benchmarked against human experts and state-of-the-art models.

MORGOTH achieved AUC-ROC 0.86–0.98 across 17 EEG findings and exceeded ≥20% of experts on every task; outperformed ≥90% of experts on 3 of 7 multi-expert-annotated datasets.

To compare the efficacy and safety of contact aspiration (CA) versus stent retriever (SR) as the first-line endovascular thrombectomy strategy in achieving first-pass effect (FPE) for patients with acute basilar artery occlusion (ABAO).

[Details see full trial entry]

To evaluate whether baseline ischemic extent (ASPECTS) modifies the efficacy and safety of intravenous tenecteplase administered before endovascular thrombectomy in acute large-vessel occlusion stroke.

In ASPECTS <8 subgroup: functional independence (mRS 0-2) significantly higher with tenecteplase + thrombectomy vs thrombectomy alone (41.6% vs 25.0%; aRR 1.67, 95% CI 1.18-2.35)

To determine whether a motivational interviewing-based intervention (MIBI) plus usual care reduces depressive symptoms 3 months after stroke compared with usual care alone and with an attention control plus usual care.

Study protocol only — no results reported yet

To assess efficacy of endovascular treatment plus best medical treatment versus best medical treatment alone at 12 months in patients with acute ischaemic stroke due to medium or distal vessel occlusion, as well as overall survival.

No difference in 12-month mRS distribution between EVT + BMT vs BMT alone (adjusted common OR 0.81, 95% CI 0.59–1.12; p=0.20)

To assess whether an intensive systolic blood pressure target (100-129 mm Hg) reduces intraparenchymal haemorrhage rates compared with a standard target (130-185 mm Hg) after successful endovascular therapy for acute ischaemic stroke.

Intensive SBP lowering (100-129 mm Hg) did NOT reduce radiographic intraparenchymal haemorrhage vs standard care (130-185 mm Hg)

In patients with acute ischaemic stroke and NIHSS ≥10 treated with intravenous alteplase, does adjunctive operator-independent 2 MHz pulsed-wave transcranial ultrasound (sonothrombolysis) improve 90-day functional outcome compared with sham ultrasound?

Primary: no shift in 90-day mRS in patients treated within 3 h (adjusted cOR 1.05, 95% CI 0.77–1.45; p=0.74).

To assess the efficacy and safety of low-dose aspirin (100 mg daily) for primary prevention of serious vascular events in persons with diabetes mellitus but no evident cardiovascular disease.

Serious vascular events reduced with aspirin: 8.5% vs 9.6% placebo (rate ratio 0.88; 95% CI 0.79-0.97; P=0.01)